Risk of Ovarian Malignancy Algorithm

Casandra

Casandra Test Code AR07333Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2012618CPT Codes 81500, 86304, 86305

Risk of Ovarian Malignancy Algorithm

Also known as: ROMA

Clinical Use

Order Test

Use

The Risk of Ovarian Malignancy Algorithm (ROMA) assesses the likelihood of malignancy in women with an ovarian adnexal mass, taking into account factors like HE4, CA125, and menopausal status. It is particularly useful for evaluating the risk of epithelial ovarian cancer in pre- and postmenopausal women before surgery. However, it is not intended as a sole method for cancer screening or monitoring and should be used alongside clinical and radiological evaluations. A ROMA score below specified thresholds for premenopausal and postmenopausal women suggests a low malignancy risk during surgical intervention.

Special Instructions

Not provided.

Limitations

ROMA should not be used as a stand-alone test for ovarian cancer screening or for monitoring purposes. It must be supplemented with HE4 and/or CA125 tests for tumor monitoring. Results obtained from different methodologies or kits are not interchangeable, which may affect consistency in diagnosis or interpretation of malignancy risk.

Test Details

New York Approved