Warfarin Sensitivity (CYP2C9, CYP2C cluster, CYP4F2, VKORC1) Genotyping
Also known as: WARF PAN
Use
Warfarin Sensitivity Genotyping is used to identify individuals with inherited gene variants that affect dose requirements for warfarin. This test predicts sensitivity to warfarin and non-standard dose requirements by analyzing genetic variants associated with warfarin metabolism and sensitivity. Variants in the genes CYP2C9, CYP2C cluster, CYP4F2, and VKORC1 are evaluated to predict dosing requirements. These genetic variations can lead to alterations in warfarin sensitivity, resulting in risk of overdose or underdose, which may cause excessive bleeding or inadequate anticoagulation.
Special Instructions
Not provided.
Limitations
The test detects only the specific targeted variants in CYP2C9, CYP2C cluster, CYP4F2, and VKORC1. It does not replace the need for clinical monitoring or therapeutic drug tests. Diagnostic errors may occur due to rare genetic variants not covered by this test. The test's results are not intended to recommend any specific medications or dosage changes. Interpretation should be done in consultation with a healthcare provider, and the test does not predict all genetic and non-genetic factors influencing warfarin dosing.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 79716-7 - CYP2C9 gene prod met act imp Bld/T-Imp
- 46724-1 - CYP2C9 allele Geno Bld/T
- 31208-2 - Specimen source
- 93197-2 - CYP4F2 c.1297G>A Geno Bld/T
- 101590-8 - VKORC1 gene allele Geno Bld/T
- 50398-7 - Narrative diagnostic report-Imp
- 101785-4 - CYP2C Clt Ale Geno Bld/T
- 81259-4 - Prob assoc phenotype
Result Turnaround Time
5-10 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
3 mL
Minimum Volume
1 mL
Container
Lavender (EDTA), pink (K2EDTA), or yellow (ACD solution A or B)
Storage Instructions
Refrigerated transport preferred
Causes for Rejection
Plasma or serum; specimens collected in sodium heparin or lithium heparin; frozen specimens in glass collection tubes
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 3 days |
| Refrigerated | 1 week |
| Frozen | 1 month |
Other tests from different labs that may be relevant