Casandra
Casandra Test Code GH13089Version 1 (DRAFT)
Performing Lab
Lab Guardant HealthLab Test ID N/A
Guardant360® Liquid
Clinical Use
Order TestUse
Guardant360® Liquid is a next‑generation sequencing (NGS)-based liquid biopsy test that analyzes circulating tumor DNA (ctDNA) to deliver comprehensive genomic and epigenomic insights for advanced solid tumors, helping guide personalized therapy selection. It is a fast comprehensive genomic profiling panel with guideline‑recommended actionable biomarkers, enabling oncologists to detect actionable somatic alterations in a minimally invasive manner and monitor tumor evolution. [Summarized]
Special Instructions
Not provided.
Limitations
Not provided.
Test Details
Methodology
NGS (Targeted)
Biomarkers
Mutation • Indel (944 genes)
ABL2ABRAXAS1ACVR1ACVR1BACVR2AADARB2ADGRA2ADGRG4AFDNAGGF1AIPAKT1AKT1S1AKT2AKT3ALBALOX12BALOX15BALOX5AMER1APEX1APLNRARAFARFRP1ARHGAP35ARID2ASXL1ATMINATRXAURKAAURKBAURKCAXIN1AXIN2AXLAAASABL1ACSL6AFF1AFF2ALKAMACRANAPC10ARHGAP26ARHGAP6ATF1ATMATRATXN7L3BABAM1BABAM2BAP1BARD1BCL2BCL2L1BCL2L2BCL6BCORBCORL1BCRBIRC5BLMBMPR1ABRCC3BRD2BRD3BRD4BSGBTG1BTG2BTKBUB1BC9orf78CALRCARD11CASP8CASRCAV1CBFBCBLCBLBCCAR1CCN6CCNA2CCNB1CCND3BCL10BCL11BBEND2BIRC3BRAFBRCA1BRCA2CAMTA1CAPZBCBFA2T3CCNE2CD274CD276CD74CD79ACD79BCDC27CDC5LCDC7CDC73CDH6CDK11ACDK7CDK8CDKN1ACDKN1CCDKN2BCDKN2CCEBPACELF4CEP295CFAP20CHD4CICCLDN18CMTM4CMTM6CNOT3CREBBPCRKLCRTC1CSF1RCSF3RCTC1CTCFCCDC32CCNB3CCND1CCND2CCR4CD38CDH1CDK12CDK6CDKN2ACDX2CEBPECHEK1CHEK2CHIC2CIAO1CIITACTLA4CTNNA1CTNNB1CUL3CUL4ACUX1CWC22CXCR4CYLDCYP17A1CYP19A1CYP2C19CYP3A4DAXXDCUN1D1DDIT3DDR1DDR2DDX17DDX18DDX27DDX3XDDX41DEPDC5DEPTORDHX15DHX16DHX36DHX9DICER1DIS3L2DLL4DNAJB1DNMT1DNMT3ADNMT3BDOT1LDPYDDUSP4DYNLL1DYRK2E2F3ECT2LEFTUD2CLIP1CLTCCOG8CPSF6CREB1CREB3L1CREB3L2CREMCSF1CXCR3CXXC5DEKDENND10DUSP22DUX4EIF1AXEIF4A1EIF4A2EIF4A3EIF4BEIF4EEIF4E2ELAVL1ELAVL2ELF3ELOCEML4EMSYEP300EPAS1EPCAMEPHA3EPHA5EPHA7EPHB1ERBB3ERBB4ERCC1ERCC2ERCC3ERCC4ERCC5ERCC6ERCC6L2ERCC8EREGERFERGERRFI1ETS1ETV1ETV4ETV5ETV6EWSR1EXO1EBF1EGFELLEPC1EPORERBB2ESR1ESRRAEXOSC1FANCAFERFGF1EZH1EZH2FAAP100FAAP20FAAP24FANCBFANCCFANCD2FANCIFANCMFASFAT1FBXW7FCGR2AFCGR3AFEN1FGF10FGF12FGF14FGF19FGF2FGF23FGF3FGF4FGF5FGF6FGF7FGF8FGF9FGFR4FHFLCNFLT1FLT3FLT4FGFR1FGFR2FGFR3FGRFIP1L1FLI1FOSFOSBFOXO1FOXO4FOXP1FOXR2FUSGATA2GATA3GLI1GLI2GLIS2GRB7GREB1FOXA1FOXL2FRS2FUBP1FUBP3FYNFZD1FZD10FZD2FZD3FZD4FZD5FZD6FZD7FZD8FZD9GAS6GATA1GATA4GATA6GEN1GID4GNA11GNA13GNAQGNASGPATCH8GPC3GREM1GRIN2AGSK3BGSTM1GSTP1H3-4HACD4HDAC2HDAC6GRM1HINFPHLFHMGA2HRASHTN3HTRA1ICA1LIDH1IDH2IGF1RIKZF1IKZF2IKZF3IL12RB1IL3INSRIRF2BP2IRF4ITKJAK1JAK2HELQHES1HEY1HEYLHGFHNF1AHNRNPDLHOXB13HSD3B1HSP90AA1ICOSLGID3IDO1IFNGIFNGR1IFNGR2IFNW1IGF1IGF2IGF2BP3IGF2RIKBKEIL1R1IL2RAIL2RBIL2RGIL7RINHBAINPP4BINTS6LIRF1IRF2IRS2JAK3JUNKAT6AJAZF1KANSL1KAT6BKDM2AKDM5AKEAP1KIF5BKITKLF2KMT2AKRASLMO1LTKLYNMAFMAFAMAFBMALT1MAML2MAN2A1KDM4AKDM5BKDM5CKDM6AKDRKINKLF4KLHL6KLHL9KMT2BKMT2CKMT2DKNSTRNLATS1LGR4LGR5LGR6LIG1LIG4LRP1BLRP2LRP5LRP6LZTR1MAD2L2MAP2K1MAP2K2MAP2K4MAP3K1MAP3K13MAP4K3MAPK1MAPK3MAPKAP1MAST1MAST2MBTD1MCRS1MDM2MDM4MEAF6MECOMMED26MEF2DMERTKMGMTMITFMLF1MLH1MLLT1MLLT10MLLT3MN1MNX1MARK2MAXMCL1MDC1MED12MEF2BMEN1MGAMKNK1MLH3MLST8MPLMRASMRE11MSH3MTHFRMTORMYBMYCLMYD88MYOD1NAB2NBNNCOR1NCR1NCR3NEGR1NELFENFE2L2MRTFAMRTFBMSANTD3MSMBMUSKMUTYHMYBL1MYCMYH11NACC1NCOA1NCOA2NCOA3NDUFAF7NF1NF2NFATC2NFKBIANHEJ1NKX2-1NOTCH1NOTCH2NOTCH3NOTCH4NOVA1NPM1NPRL2NPRL3NRASNSD1NSD2NSD3NSRP1NTHL1NUMA1NUMBNUP93NUTM1P2RY8PABPC1PAK1PAK3PARGPARP1PARP2PAX3PAX5PAX7PAX8PAXIP1PCBP1PCBP2PCDH15PDCD1PDCD1LG2NFIBNFIXNFKB2NIPBLNR4A3NRF1NRG1NTRK1NTRK2NTRK3NUMBLNUP214NUP98PDE7APDGFRBPDK1PDPK1PHF6PHLPP1PHLPP2PHOX2BPIAS4PIK3C2BPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIM1PIN1PKMPLCG2PLEKHS1PLRG1PMS1POLA1POLD1POLHPOLQPOT1POU2F2PPARGPPIGPPM1DPPP2CAPPP2R1APPP2R2APPP3CAPPP6CPRDM1PREX1PREX2NUTM2AOGAOPHN1PAG1PALB2PAN3PBX1PBX3PCM1PDGFBPDGFDPDGFRAPGRPHF1PHKBPICALMPRKAR1APRKCIPRKDCPRKNPRMT5PRPF40BPSENENPSMB10PSMB8PSMB9PTCH1PTDSS1PTPN11PTPN2PTPRDPTPRSPTPRTQKIRAB35RAC1RAD18RAD21RAD51BRAD52RAD54LRAET1ERARARASA1RBBP6RBM10RBMXRECQLRECQL4REV3LRGS1PIK3CAPKN1PLAG1PLAGL1PMLPOU2AF3PRDM10PRDM16PRKACAPRKACBPRKCAPRKCBPRKCDPRKD1PRKD2PRKD3PTK2BPVT1RHEBRHOARHOBRICTORRIF1RILPL1RIT1RNASEH2BRNF43ROBO1ROBO2RPA1RPS27ARPS6KA3RPS6KB1RPS6KB2RPTORRRAGCRSPO1RSPO2RSPO4RUNX1RUNX1T1RXRARYBPSAMHD1SDC4SDHAF2SEM1SERPINB3SERPINB4SESN2SETD2SF3B1SF3B3SH2D1ASHLD1SHLD2SLC34A2RAD51CRAF1RARGRASGRF1RB1RBM15RELARETRNF10ROS1RPN1RREB1RRP8RSPO3SEC61GSFMBT1SLFN11SLIT2SMAD2SMAD3SMARCA2SMARCA4SMARCAL1SMARCB1SMARCD1SMARCE1SMC1ASMC3SMOSNCAIPSOCS1SOCS3SOS1SOX10SOX17SOX2SOX9SPENSPOPSRCSRSF2SRYSS18STAG2STAT1STAT3STAT4STK19STK40STN1SUFUSYKSYNCRIPTACSTD2TAF1LTAP1TAP2TAPBPSLC1A2SLC45A2SLC45A3SNRNP27SRFSS18L1SSX1SSX2SSX4ST3GAL1STAT5BSTAT6STK11STK24SUZ12SYF2TAF15TBL1XR1TBX21TBC1D7TBX3TCERG1TCF7L2TEKTEN1TENT5CTERTTET1TET2TFE3TFRCTGFBR1TGFBR2THRAP3TIA1TIPARPTMEM127TMPRSS2TNFAIP3TNFRSF14TNFRSF1ATNK2TNPO1TOP1TOP2ATOPAZ1TP53BP1TP63TP73TPMTTRAF2TRAF3TRAF7TRIM24TRIP13TSC1TSHRTSHZ2TYMPTYMSTYRO3TCF12TCF3TCL1ATECTFCP2TFEBTFGTGFBR3THADATNFRSF17TRAPPC12TRIM11TRMT11TYK2U2AF1UBE2TUGT1A1UIMC1ULBP1ULBP3USP28USP7USP9XVEGFAVEGFBVHLVIRMAWBP11WEE1WRNWT1WWP1XBP1XPAXPCXPO1XRCC1XRCC2XRCC3XRCC4XRCC5XRCC6YAP1YES1ZC3H13ZC3H18ZC3H4ZMYM3ZNF217ZNF703ZNRF3ZRSR2UBA1UBTFUSP6VGLL2VGLL3VIMWDR33WWTR1APCARARID1AARID1BB2MBRIP1CCNE1CDK4CDKN1BEGFRFANCEFANCFFANCGFANCLMETMSH2MSH6MTAPMYCNPBRM1PMS2POLEPTENRAD50RAD51RAD51DSDHASDHBSDHCSDHDSMAD4TP53TSC2C11orf95H3F3APRPF4B
MSI
SignatureMSI-High
Microsatellite Instability (MSI) • Composite / Signature
TMB
SignatureTumor Mutation Burden
Tumor Mutational Burden (TMB) • Composite / Signature
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Plasma
Volume
Not provided
Minimum Volume
Not provided
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