α1-Antitrypsin Phenotyping
Also known as: Alpha1-Antitrypsin Phenotyping, Pi Phenotype, Protease Inhibitors
Use
Definitive analysis of hereditary α1-antitrypsin deficiency, which is associated with chronic obstructive pulmonary disease (COPD) (panacinar emphysema), hepatic cirrhosis, and hepatoma. Cholestasis with neonatal hepatitis is found in a minority of neonates with α1AT deficiency.
Special Instructions
Not provided.
Limitations
α1-antitrypsin therapy may alter the patient's phenotype, potentially affecting test results. Patients may have falsely normal levels during respiratory inflammation such as bronchitis or pneumonia, requiring retesting post-illness to determine the true α1-antitrypsin level. Serum levels may be influenced by a range of conditions including pregnancy, chronic pulmonary diseases, and others.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
Phenotype (PI)
Proteinα1-antitrypsin, total, serum
Analyte
LOINC Codes
- 6770-2 - A1AT Phenotyp SerPl IFE
- 1825-9 - A1AT SerPl-mCnc
- 6770-2 - A1AT Phenotyp SerPl IFE
Result Turnaround Time
3-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.7 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells.
Patient Preparation
Overnight fasting is preferred.
Storage Instructions
Room temperature storage is acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 21 days |
| Refrigerated | 21 days |
| Frozen | 21 days |
Other tests from different labs that may be relevant