17-OH Progesterone, LC/MS, Two Specimens
Use
The 17-OH Progesterone test utilizing Liquid Chromatography-Mass Spectrometry (LC/MS) is crucial for evaluating individuals suspected of having congenital adrenal hyperplasia (CAH), particularly in newborns and children. This test measures levels of 17-hydroxyprogesterone, a steroid hormone produced by the adrenal glands that is a marker used to assess adrenal gland function. Elevated levels of 17-OH progesterone can indicate adrenal hyperplasia due to enzyme deficiencies, such as 21-hydroxylase deficiency.
Special Instructions
This panel is part of a series of tests that require multiple specimens to be collected at different time points. An initial baseline tube is collected, followed by treatment with a drug or agent, such as glucola, and subsequent samples are taken after the treatment. It is imperative that this series panel not be collected unless the clinician has instructed and justified its use, particularly because it involves treatments like medication administration.
Limitations
The test's analytical performance is defined by LabCorp, and it has not been cleared or approved by the FDA. It is important to consider the variations in hormone levels that can occur due to physiological factors such as the phase of the menstrual cycle or the time of day. Additionally, pre-analytical variables such as specimen handling or patient's treatment regimen can impact the results. Results should be interpreted in the context of the overall clinical picture and other laboratory findings.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 27996-8
- 51680-7
- 46963-5
Result Turnaround Time
4-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
Not provided
Minimum Volume
Not provided