α2-Antiplasmin
Also known as: Alpha-2-Antiplasmin
Use
The most important inhibitor to plasmin, α2-antiplasmin prevents plasmin action on fibrin during fibrinolysis. Decreased levels may lead to easy bruising, epistaxis, hematuria, menorrhagia, hemarthrosis, and bleeding after trauma or surgery.
Special Instructions
Each factor assay requested must have its own separate aliquot of plasma. Special attention must be given if the patient's hematocrit exceeds 55%, requiring an adjustment of the citrate volume in the collection tube. Proper blood collection technique is vital to ensure accurate results, and it is necessary to follow the specific coagulation collection procedures. It is recommended to have separate frozen specimens for each test in cases of multiple test requests to avoid delays in results.
Limitations
There are no specific limitations mentioned; however, the test may have typical constraints associated with coagulation tests, such as issues with sample collection, transport, and handling that could affect the integrity of the specimen. Specific criteria for sample rejection include severe hemolysis, improper labeling, improper sample type, and specimens that are clotted, diluted with IV fluids, or thawed during transit. Adherence to detailed collection guidelines is essential to mitigate these risks.
Methodology
Other
Biomarkers
LOINC Codes
- 27810-1
- 27810-1
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
1 mL
Minimum Volume
Not provided
Container
Blue-top (sodium citrate) tube
Collection Instructions
Citrated plasma samples should be collected by double centrifugation. Blood should be collected in a blue-top tube containing 3.2% buffered sodium citrate. Evacuated collection tubes must be filled to ensure a proper blood-to-anticoagulant ratio. The sample should be mixed immediately by gentle inversion at least six times. A discard tube is required only when using a winged collection device. After initial centrifugation, remove two-thirds of the plasma, recapitulate, recentrifuge, and transfer the plasma into a Labcorp PP transpak frozen purple tube with screw cap. Freeze immediately and maintain frozen until tested.
Patient Preparation
None
Storage Instructions
Freeze.
Causes for Rejection
Severe hemolysis, improper labeling, clotted specimen, specimen diluted with IV fluids, samples thawed in transit, improper sample type, sample out of stability
Stability Requirements
| Temperature | Period |
|---|---|
| Frozen | 14 days; stable through 3 freeze/thaw cycles |