Adrenocorticotropic Hormone (ACTH), Plasma, Eight Specimens

Casandra

Casandra Test Code LC84374Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 267708CPT Code 82024

Adrenocorticotropic Hormone (ACTH), Plasma, Eight Specimens

Clinical Use

Use

The Adrenocorticotropic Hormone (ACTH) Plasma test is used to diagnose or rule out conditions related to abnormal hormone levels, such as Cushing's disease and Addison's disease. The test is generally ordered as part of a series for dynamic endocrine testing, which requires drawing multiple specimens over time to evaluate the patient's response to a stimulus, such as a medication or a physiological challenge. Monitoring ACTH levels can help guide treatment and management of disorders affecting the pituitary gland or adrenal glands.

Special Instructions

This test requires careful coordination and timing as it involves the collection of eight separate plasma specimens at defined intervals, typically in response to an administered medication or treatment (e.g., glucola). Physicians must be consulted before the series is ordered to ensure the necessity of the testing. Additionally, patients should discontinue biotin supplements at least 72 hours prior to specimen collection to avoid assay interference.

Limitations

This test may not be accurate for patients currently taking or recently having taken biotin supplements, as high doses can interfere with the assay results. Proper timing and adherence to specimen collection procedures are crucial for reliable results. The test also requires careful handling and processing of multiple time-point specimens, which may introduce variability if not managed correctly.

Test Details

Methodology

Immunoassay (CLIA)

Biomarkers

Adrenocorticotropic Hormone

Analyte

ACTH #1 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #2 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #3 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #4 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #5 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #6 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #7 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

ACTH #8 • Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)

LOINC Codes

Order Codes

42598-3

Result Codes

42598-3
39564-0
12458-6
12459-4
12460-2
12461-0
12462-8
12463-6

Result Turnaround Time

1-2 days

Specimen

Plasma

Volume

Not provided

Minimum Volume

Not provided

Container

Special ACTH tube

Collection Instructions

Collect blood in a special ACTH tube. Multiple specimens should be collected at specific time intervals as prescribed. Ensure tubes are labeled in sequence and transport them promptly to the laboratory.

Patient Preparation

Patients should discontinue biotin supplements at least 72 hours prior to specimen collection.

Storage Instructions

Plasma should be separated and frozen if not immediately transported to the lab.

Causes for Rejection

Specimens collected from patients consuming high doses of biotin.

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