Allergen Profile, Milk, IgE With Component Reflexes
Use
The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-4 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CDR can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.
Special Instructions
Not provided.
Limitations
Allergen-specific IgE assays do not provide absolute positive or negative predictive values for allergic disease. Clinical history should be integrated into the diagnostic process. Although component resolved IgE testing enhances evaluation over whole extracts alone, it cannot replace clinical history or oral food challenge in most cases. Unidentified determinants not present in extracts or components may cause rare symptoms.
Methodology
Immunoassay (ELISA)
Biomarkers
Bos d 4, α-lactalbumin
ProteinBos d 5, β-lactoglobulin
ProteinBos d 8, Casein
Protein
LOINC Codes
- 7258-7 - Cow Milk IgE Qn
- 8251-1 - Service Cmnt-Imp
- 7258-7 - Cow Milk IgE Qn
- 7445-0 - A-Lactalb IgE Qn
- 41397-1 - Deprecated B-Lactoglob IgE Qn
- 6062-4 - Casein IgE Qn
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
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