Allergen Profile, Peanut, IgE With Component Reflexes
Use
The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-5 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CDR can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.
Special Instructions
Not provided.
Limitations
Allergen-specific IgE assays do not have absolute predictive values for allergic disease. While component resolved IgE testing may enhance evaluation over whole extracts, it does not replace clinical history and oral food challenges in most cases. Sensitization against unidentified determinants not found in extracts or components might cause symptoms rarely. The presence of IgE to certain components augments risk assessment but does not alone confirm or exclude clinical allergy.
Methodology
Immunoassay (Multiplex Protein Panel)
Biomarkers
LOINC Codes
- 6251-1
- 6206-7 - Peanut IgE Qn
- 58779-0 - Peanut (rAra h) 1 IgE Qn
- 58778-2 - Peanut (rAra h) 2 IgE Qn
- 58777-4 - Peanut (rAra h) 3 IgE Qn
- 90880-6 - Peanut (rAra h) 6 IgE Qn
- 63477-4 - Peanut (rAra h) 8 IgE Qn
- 64965-7 - Peanut (rAra h) 9 IgE Qn
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
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