Allergen Profile, Peanut, IgE With Component Reflexes

Casandra

Casandra Test Code LC82627Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 603916CPT Code 86003

Allergen Profile, Peanut, IgE With Component Reflexes

Clinical Use

Use

The measurement of specific immunoglobulin E (IgE) to individual components of an allergen, either purified native or recombinant, is referred to as component resolved diagnosis (CRD).1-5 This approach represents an improvement over traditional measurement of IgE to allergen extracts that contain a mixture of proteins. The pattern of specific IgE reactivity to component allergens can predict which patients are at higher risk for systemic allergic reactions versus those who are sensitized but clinically tolerant. CDR can also be used to predict which patients are at risk for more severe reactions and which patients are likely to have milder symptoms.

Special Instructions

The test reflexes criteria: If whole peanut IgE is ≥0.10 kU/L, then further testing for components Ara h 1, Ara h 2, Ara h 3, Ara h 6, Ara h 8, and Ara h 9 will be performed. Pediatric populations or patients with known birch pollen sensitivity might show cosensitization with peanut components like Ara h 8.

Limitations

Allergen-specific IgE assays do not have absolute predictive values for allergic disease. While component resolved IgE testing may enhance evaluation over whole extracts, it does not replace clinical history and oral food challenges in most cases. Sensitization against unidentified determinants not found in extracts or components might cause symptoms rarely. The presence of IgE to certain components augments risk assessment but does not alone confirm or exclude clinical allergy.

Test Details