Anti-Aquaporin 4 (AQP4), Serum
Use
This test is used for evaluation of patients with suspected Neuromyelitis Optica Spectrum Disorder (NMOSD).
Special Instructions
Not provided.
Limitations
The absence of AQP4 antibodies does not rule out NMOSD due to possible false-negatives, particularly if the patient is under immunosuppressive therapy. Antibody levels might increase during relapse and decrease with therapy; however, titer changes may not predict clinical relapses. Results should not inform diagnosis without confirmation from other diagnostic methods. This test's performance characteristics were established by LabCorp and have not been approved by the FDA.
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
AQP4 (Anti-Aquaporin 4)
Protein
LOINC Codes
- 95272-1 - AQP4 H2O channel IgG Ser Ql CBA IFA
- 95272-1 - AQP4 H2O channel IgG Ser Ql CBA IFA
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Serum from red-top tube
Storage Instructions
Room temperature
Causes for Rejection
Gross hemolysis; grossly lipemic; serum separator tube (SST)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
Other tests from different labs that may be relevant