Anti-N-methyl-D-Aspartate Receptor (NMDAR), Serum
Use
NMDAR1 is a glutamate receptor and ion channel found in neurons. This receptor is thought to be very important for controlling synaptic plasticity and mediating learning and memory functions. Antibodies against NMDAR1 generate both neurologic and psychiatric symptoms. Common symptoms include personality change, psychosis, abnormal movements, seizures and autonomic dysfunction. Anti-NMDA receptor IgG antibody is found in a subset of patients with autoimmune limbic encephalitis and may occur with or without associated tumor. Decreasing antibody levels may be associated with therapeutic response; therefore, clinical correlation must be strongly considered. A negative test result does not rule out a diagnosis of autoimmune limbic encephalitis.
Special Instructions
Not provided.
Limitations
The test results should not be used as a sole diagnostic procedure but must be confirmed by another medically established diagnostic product or procedure. The test has been developed and its performance characteristics established by Labcorp, but it has not been cleared or approved by the FDA.
Methodology
Immunoassay (Immunofluorescence)
Biomarkers
NMDAR1
Protein
LOINC Codes
- 93870-4 - NMDAR1 Ab Ser Ql CBA IFA
- 93870-4 - NMDAR1 Ab Ser Ql CBA IFA
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Serum from a gel-barrier tube, serum from a red-top tube, gel-barrier tube, serum transfer tube
Storage Instructions
Room temperature
Causes for Rejection
CSF or plasma; contaminated, hemolyzed, or severely lipemic specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |
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