Anticardiolipin Antibodies (ACA), IgA, Quantitative
Also known as: Antiphospholipids, Cardiolipin Antibodies
Use
Anticardiolipin antibodies are often present in individuals with the antiphospholipid antibody syndrome.1,2
Special Instructions
Patients who test positive for ACA should be retested after six to eight weeks to rule out transient antibodies that do not indicate APS. Due to the heterogeneity of antibodies associated with APS, both LA and ACA testing is recommended when APS is suspected.
Limitations
ACA can often be observed during convalescent phases of infections and in syphilis, typically not linked to clinical complications. False positives may arise from other autoimmune conditions or drug-induced antibodies. The diagnosis of APS should not be solely made based on a single ACA result, as many antibodies detected are transient and not clinically significant.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 5076-5
- 5076-5
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; lipemia; icteric specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days |