Anticentromere B Antibodies
Also known as: Antinuclear Antibodies (ANA)
Use
The Anticentromere B Antibodies test is used in the diagnosis of certain autoimmune conditions, such as systemic sclerosis or scleroderma, where these antibodies may be present. The presence of anticentromere antibodies is associated with the CREST variant of scleroderma, which includes calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasia. This test helps in assessing the likelihood of these conditions and can aid in the differential diagnosis when symptoms suggest an autoimmune etiology.
Special Instructions
This test requires a serum specimen collected in a red-top tube or gel-barrier tube. Ensure adequate volume to allow for repeat testing if necessary; the minimum volume does not permit retesting. Maintain stable conditions through room temperature, refrigeration, or freezing methods as specified for up to 14 days.
Limitations
The Anticentromere B Antibodies test may not detect all potential centromere antibodies. In cases where other clinical symptoms or tests indicate an autoimmune disorder, additional investigations may be required to confirm or rule out the diagnosis. Hemolysis, icterus, lipemia, and bacterial contamination can lead to test rejection, impacting the accuracy of results.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 53982-5
- 53982-5
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
Red-top tube or gel-barrier tube
Storage Instructions
Room temperature
Causes for Rejection
Hemolysis; icterus; lipemia; bacterial contamination
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |