Antidiuretic Hormone (ADH), Plasma
Also known as: Arginine Vasopressin, AVP, Vasopressin
Use
Useful for the differential diagnosis of patients with water balance disorders, including diabetes insipidus in conjunction with osmolality and hydration status
Special Instructions
Test requires plasma specimen to be centrifuged in a refrigerated centrifuge, separated, and frozen immediately for transfer. No isotopes should be administered within 24 hours prior to venipuncture. To prevent delays, submit separate frozen specimens for multiple test requests.
Limitations
This test has not been FDA-cleared or approved. ADH is released in a pulsatile manner and rapidly cleared, which presents a challenge for its assessment. The peptide's high ex vivo instability complicates measurement. Mixed forms of DI and the potential for incomplete central and peripheral DI add complexity to interpreting results.
Methodology
Immunoassay (RIA)
Biomarkers
LOINC Codes
- 3126-0
- 3126-0
Result Turnaround Time
4-12 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
Not provided
Container
Lavender-top (EDTA) tube
Collection Instructions
Centrifuge in a refrigerated centrifuge, separate plasma, and freeze immediately. Transfer specimen to a plastic transport tube before freezing. Submit separate frozen specimens for each test requested to avoid delays.
Patient Preparation
No isotopes administered within 24 hours prior to venipuncture.
Storage Instructions
Freeze.
Causes for Rejection
Recently administered isotopes; plasma specimen not received frozen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unstable |
| Refrigerated | Unstable |
| Frozen | 4 weeks |