CML FISH Reflex to JAK2V617F Mutation Analysis, Quantitative, With Reflex to CALR Mutation Analysis, JAK2 Exon 12-15 Mutation Analysis and MPL Mutation Analysis by NGS
Use
This test is used to confirm the diagnosis of CML, establish the chronic phase karyotype for comparison with blast crisis alterations and monitor residual disease.
Special Instructions
It is advised to include pertinent clinical diagnosis and previous cytogenetic studies on the test request form for an accurate analysis. Utilize sterile technique and Labcorp transport kits when possible to ensure specimen integrity.
Limitations
This test will not detect molecular mutations or chromosomal alterations not targeted by the included probes. Additionally, the test's performance characteristics were internally determined by Labcorp and have not been cleared or approved by the Food and Drug Administration, which may limit its application in certain regulatory environments.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
LOINC Codes
- 31208-2
- 48672-0
- 50398-7
- 51867-0
- 62360-3
- 62361-1
- 62361-1
- 62360-3
- 51867-0
- 50398-7
- 31208-2
- 48672-0
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
2 mL
Minimum Volume
1 mL
Container
Green-top sodium-heparin tube
Collection Instructions
Utilize sterile technique and Labcorp transport kits when possible.
Storage Instructions
Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.
Causes for Rejection
Broken Vacutainer®; broken or stained slides; decalcified bone core; frozen specimen; quantity not sufficient for analysis