Complement C1 Esterase Inhibitor
Also known as: C1 Esterase Inhibitor, Antigen, C1 Inactivator, C1 Inhibitor, Esterase Inhibitor, HANE Assay
Use
C1 esterase inhibitor is decreased in hereditary angioneurotic edema; decrease may be functional or quantitative
Special Instructions
Separate serum from cells within 30 to 60 minutes after collection. Transfer specimen to a plastic transport tube. Serum must be maintained at room temperature for stability. Testing may require additional time for reflex or confirmatory tests.
Limitations
The test may have limitations in distinguishing between hereditary and acquired forms of C1 esterase deficiency, especially if quantitative levels appear normal but a functional defect exists. Misidentification due to sample contamination or improper handling can lead to false results.
Methodology
Immunoassay (Immunologic, quantitative)
Biomarkers
LOINC Codes
- 4477-6
- 4477-6
Result Turnaround Time
3-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from cells within 30 to 60 minutes after collection. Transfer specimen to a plastic transport tube.
Storage Instructions
Maintain specimen at room temperature.
Causes for Rejection
Microbially-contaminated samples; hemolysis; gross lipemia that cannot be cleared by ultracentrifugation; citrated plasma (heparinized plasma is acceptable)
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |