Complete Blood Count (CBC) With Differential, Reflex to Peripheral Smear Review

Clinical Use

Use

As a screening test to evaluate overall health; detect and/or identify a wide range of hematologic disorders; assist in managing medications/chemotherapeutic decisions

Special Instructions

Not provided.

Limitations

The CBC with differential provides a broad overview but may not definitively diagnose hematologic disorders as many abnormalities are nonspecific. Some results require further confirmatory tests or reflexive analyses, such as manual differentials or peripheral smear exams, especially when detecting morphologic abnormalities in blood cells. Interpretive caution is needed in the absence of clinical context or other diagnostic criteria.

Test Details

Methodology

Automated Analyzer (Hematology)

Biomarkers

9 targets

HematocritHemoglobinMCHMCHCMCVPlatelet Count (PLT)Red Cell Count (RBC)Red Cell Distribution Width (RDW)+1 more

LOINC Codes

Order Codes

57021-8 - CBC W Auto Diff Bld

Result Codes

75652-8 - Imm Lymphs Bld Ql
751-8 - Neutrophils # Bld Auto
731-0 - Lymphocytes # Bld Auto
742-7 - Monocytes # Bld Auto
711-2 - Eosinophil # Bld Auto
704-7 - Basophils # Bld Auto
71695-1 - Imm Granulocytes NFr Bld Auto
53115-2 - Imm Granulocytes # Bld Auto
58413-6 - nRBC Bld Auto-Rto
18314-5 - Morphology Bld-Imp
6690-2 - WBC # Bld Auto
789-8 - RBC # Bld Auto
718-7 - Hgb Bld-mCnc
4544-3 - Hct VFr Bld Auto
787-2 - MCV RBC Auto
785-6 - MCH RBC Qn Auto
786-4 - MCHC RBC Auto-EntMCnc
788-0 - Erythrocyte DistWidth Bld Auto
777-3 - Platelet # Bld Auto
770-8 - Neutrophils NFr Bld Auto
736-9 - Lymphocytes NFr Bld Auto
5905-5 - Monocytes NFr Bld Auto
713-8 - Eosinophil NFr Bld Auto
706-2 - Basophils NFr Bld Auto

Result Turnaround Time

1 day

Specimen

Whole Blood

Volume

Fill tube to capacity.

Minimum Volume

0.5 mL (500 μL for pediatric microtainer capillary tubes; fill tube to capacity)

Container

Lavender-top (EDTA) tube

Collection Instructions

Invert tube 8 to 10 times immediately after tube is filled at the time of collection.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Hemolysis; clotted specimen; specimen drawn in any anticoagulant other than EDTA; specimen diluted or contaminated with IV fluid; tube not filled with minimum volume; improper labeling; transfer tubes with whole blood; specimen received with plasma removed (plasma is used for other testing)