Fibrinolysis Profile II (Esoterix)
Use
The Fibrinolysis Profile II (Esoterix) test is used to assess various components of the fibrinolytic system, which is the body's process of breaking down clots. This test evaluates the levels and activity of key fibrinolytic markers and proteins, helping in the diagnosis and management of disorders involving excessive clotting or bleeding. It includes the measurement of alpha-2 antiplasmin, D-dimer, euglobulin lysis time, fibrin degradation products, plasminogen activator inhibitor 1 activity, plasminogen activity, and tissue plasminogen activator antigen.
Special Instructions
Plasma must be separated from cells within 45 minutes of venipuncture and must be centrifuged a second time before transferring to plastic transport tubes. Samples should be frozen within two hours and remain frozen until testing. Separate submissions are required for each test requested to prevent delays in turnaround times.
Limitations
This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration. D-Dimer test results can be used as an aid in the diagnosis of venous thrombosis but are not FDA approved for this exclusion.
Methodology
Other
Biomarkers
LOINC Codes
- 27810-1
- 48065-7
- 30226-5
- 5975-8
- 28660-9
- 5971-7
- 40454-1
Result Turnaround Time
4-11 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
Four 2-mL platelet-poor, frozen tubes
Minimum Volume
Not provided
Container
Blue-top (sodium citrate) tubes
Collection Instructions
Plasma must be separated from cells within 45 minutes of venipuncture and centrifuged a second time before transferring to plastic transport tubes. Freeze within two hours and keep frozen until testing is performed.
Storage Instructions
Freeze
Causes for Rejection
Noncitrated plasma; gross hemolysis; presence of fibrin; clotted plasma