Hepatitis B Virus (HBV) Prenatal Screen With Reflex to HBV DNA
Use
Screening of pregnant women for hepatitis B virus (HBV) infection to identify neonates who are at risk of acquiring hepatitis B during the perinatal period. A positive HBsAg test will reflex to HBV quantitative DNA.
Special Instructions
Not provided.
Limitations
Patients who are negative for HBsAg may still have acute type B viral hepatitis due to antigen levels below the detection limit of the assay or lack of antigen reactivity. Strong clinical suspicion of viral hepatitis should lead to a comprehensive test battery that includes detection of antibodies hepatitis B core antigen (anti-HBc) and HBV DNA.
Methodology
Immunoassay (ICMA)
Biomarkers
HBV DNA
ProteinHepatitis B surface antigen (HBsAg)
Protein
LOINC Codes
- 5196-1 - HBV surface Ag SerPl Ql IA
- 5196-1 - HBV surface Ag SerPl Ql IA
- 7905-3 - HBV surface Ag SerPl Ql Nt
- 42595-9 - HBV DNA SerPl NAA+probe-aCnc
- 48398-2 - HBV DNA SerPl NAA+probe-Log IU
- 19147-8 - Ref Lab Test Ref Range
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
6 mL
Minimum Volume
2.2 mL
Container
Gel-barrier tube or serum transfer tube
Collection Instructions
Centrifuge sample within 24 hours of collection. If a tube other than a gel-barrier tube is used, or if the sample will be shipped frozen, transfer separated serum to a screw-cap polypropylene transport tube. Do not freeze gel-barrier tube; pour off serum first.
Causes for Rejection
Non-EDTA plasma specimen; PST gel-barrier tube
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | HBsAg: Room temperature up to 14 days. |
| Refrigerated | HBsAg: Refrigerated up to 14 days. |
| Frozen | HBsAg: Frozen up to 7 days. HBV DNA: Frozen (preferred) up to 12 weeks. |
Other tests from different labs that may be relevant