Human Immunodeficiency Virus 1 (HIV-1) GenoSure Archive® Plus Trofile® DNA
Also known as: Cell-associated Viral DNA, HIV-1 Genotype, Resistance Analysis
Use
Detect resistance of HIV-1 to protease, reverse transcriptase, and integrase inhibitors (GenoSure Archive®) and detect HIV-1 coreceptor tropism (Trofile® DNA) in cell-associated viral DNA; determine eligibility for CCR5 antagonist therapy, such as maraviroc (Selzentry®).
Special Instructions
Not provided.
Limitations
This test should only be used for patients with documented HIV-1 infection who have an undetectable viral load or low-level viremia. It is important to note that the test has not been cleared or approved by the Food and Drug Administration and thus may have limitations in terms of its validation for clinical use. Additional confirmatory or reflex tests might be required, which could affect the turnaround time.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 51969-4 - Gene analysis narr rpt Doc
- 62364-5 - Test performance info Spec
- 80693-5 - HIV1 provir DNA RT + PR + IN Mut Det Seq
- 80694-3 - HIV1 proviral DNA Gentyp Bld MC Nar
- 80695-0 - HIV 1 proviral DNA Gentyp Bld MC Doc
- 50790-5 - HIV1 RNA tropism Islt
- 80690-1 - HIV1 proviral DNA tropism Bld MC
Result Turnaround Time
24-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
8 mL
Minimum Volume
Not provided
Container
Lavender-top (EDTA) tube
Collection Instructions
Collect specimen in two lavender-top (EDTA) tubes. Do not centrifuge. Ship frozen.
Storage Instructions
Freeze.
Causes for Rejection
Quantity not sufficient for analysis; heparinized plasma; nonfrozen specimen
Other tests from different labs that may be relevant