IGHV Somatic Hypermutation
Also known as: IgVH Gene Mutation, Immunoglobulin Heavy Chain Variable Region Somatic Hypermutation Analysis
Use
Determines the mutation status of IgVH gene in B lymphocytes, including those of CLL (chronic lymphocytic leukemia). The IgVH gene mutation status is one of the discriminators of clinical outcome in patients with CLL. The mutational status of the immunoglobulin genes expressed by CLL cells can be used to segregate patients into two subsets that have significantly different tendencies for disease progression. Patients with leukemic cells that express unmutated immunoglobulin heavy-chain variable region genes have a greater tendency for disease progression than those who have leukemic cells that express IgVH genes with less than 98% nucleic acid homology with their germ-line counterparts.
Special Instructions
Not provided.
Limitations
This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 62365-2 - Diagnostic imp Spec-Imp
- 80563-0 - Report
Result Turnaround Time
6-8 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
1 mL
Minimum Volume
0.5 mL
Container
Lavender-top (EDTA) tube, green-top (heparin) tube or yellow-top (ACD) tube
Storage Instructions
Maintain specimen at room temperature; stable for three to five days.
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