Immunoglobulin M (IgM) Heavy and Light Chain (HLC) Pairs, κ and λ With Ratio
Also known as: Hevylite IgM, HLC IgM, IgM κ:λ HLC Ratio
Use
For the quantitative measurement of human IgM heavy chain and light chain intact immunoglobulin in serum. The test result is to be used with previously diagnosed Waldenström's macroglobulinemia in conjunction with other clinical and laboratory findings. This assay has not been established for the diagnosis, monitoring, and prognosis of Waldenström's macroglobulinemia.
Special Instructions
Not provided.
Limitations
Decisions on patient evaluation and management must not be based solely on IgM κ, IgM λ, or IgM κ:IgM λ ratio. Clinical history and other lab findings must be considered; HLC quantitation should complement serum protein electrophoresis, and therapy effects have not been fully evaluated. Small monoclonal concentration changes may not alter the HLC ratio.
Methodology
Immunoassay (Turbidimetric)
Biomarkers
Result Turnaround Time
4-6 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.75 mL
Minimum Volume
0.5 mL
Container
Red-top tube or gel‑barrier tube
Collection Instructions
Separate serum immediately after coagulation (30 minutes) to prevent hemolysis.
Storage Instructions
Refrigerate.
Causes for Rejection
Microbially‑contaminated specimen; specimen containing particulate matter; lipemic or hemolyzed specimen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 14 days |
| Frozen | 14 days |