Immunoglobulins IgA, IgG, IgM, Cerebrospinal Fluid
Use
Evaluate electrolyte composition of urine, acid-base balance studies. Distinguish whether or not a case of metabolic alkalosis is chloride-responsive (salt responsive). Sherman and Eisinger1,2 discuss bicarbonate excretion, blood volume, potassium depletion, and the differential diagnosis of metabolic alkalosis with loss of gastric juice (emesis, intubation) and after diuretics. Chloride depleted patients excrete urine with low chloride, <10 mmol/L. Such patients are chloride-responsive (ie, they respond to chloride sufficient to return body stores to normal). Metabolic alkalosis with low urine chloride is also found with villous tumors of the colon.
Special Instructions
Not provided.
Limitations
Halogens other than chloride (bromide), which are also present in urine may erroneously elevate the chloride result. Isolated urine chloride, without urine sodium or potassium or without serum electrolytes, can provide misleading information. Discussion of electrolyte balance is beyond the scope of this manual (eg, effect of profound potassium depletion on impairment of chloride reabsorption). Fetal urinary electrolytes are an unreliable guide to evaluate fetal renal function.3
Methodology
Colorimetric; ion-selective electrode (ISE)
Biomarkers
LOINC Codes
- 2079-2 - Chloride 24h Ur-sRate
- 21194-6 - Chloride 24h Ur-sCnc
- 2079-2 - Chloride 24h Ur-sRate
- 2464-6 - IgG CSF-mCnc
- 2457-0 - IgA CSF-mCnc
- 2471-1 - IgM CSF-mCnc
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Unknown
Volume
Not provided
Minimum Volume
Not provided
Causes for Rejection
Improper labeling
Other tests from different labs that may be relevant