Lipid Panel With Diabetes Risk Index (DRI)

Casandra

Casandra Test Code LC30459Version 1 (DRAFT)

Performing Lab

Lab LabcorpLab Test ID 123525CPT Codes 80061, 81599

Lipid Panel With Diabetes Risk Index (DRI)

Clinical Use

Use

The Diabetes Risk Index (DRI) is intended for use in adult subjects for the quantitative determination of a risk score in serum or plasma. The DRI score (1-100) may be used as an aid in stratifying the risk of developing type 2 diabetes in individuals with normo-glycemia or prediabetes. The Diabetes Risk Index (DRI) is a nuclear magnetic resonance spectroscopy (NMR)-derived multimarker score (values 1-100) that predicts a patient's risk of developing type 2 diabetes mellitus (T2D) independent of glycemic status. DRI derives its performance from the weighted addition of the Lipoprotein Insulin Resistance Index (LP-IR) scores with simultaneously-measured levels of branched-chain amino acids (BCAA).1-6

Special Instructions

Not provided.

Limitations

LDL cholesterol will not be calculated if triglyceride levels are above 800 mg/dL. DRI measurements from plasma specimens are typically 8 points lower than those obtained from serum specimens. This test has not been cleared or approved by the FDA.

Test Details

Methodology

Other

Biomarkers

Cholesterol, totalDiabetes Risk Index (DRI)High-density lipoprotein (HDL) cholesterolLow-density lipoprotein (LDL) cholesterol (calculation)Non-high-density lipoprotein (non-HDL) cholesterol (calculation)Triglycerides

LOINC Codes

Result Codes

2093-3 - Cholest SerPl-mCnc
2571-8 - Trigl SerPl-mCnc
2085-9 - HDLc SerPl-mCnc
43396-1 - NonHDLc SerPl-mCnc
13457-7 - LDLc SerPl Calc-mCnc
94560-0 - Diabetes risk Scre Calc

Result Turnaround Time

1-3 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Plain red-top tube (preferred); NMR LipoTube (black-and-yellow-top tube)

Collection Instructions

Collect specimen in a plain red-top tube (no gel), hold upright at room temperature for 45 minutes to clot, then centrifuge. Transfer to a transport tube for storage at 2°C to 8°C until shipment.

Patient Preparation

Patient fasting is not required but recommended for certain conditions.

Storage Instructions

Refrigerate.

Causes for Rejection

Unspun LipoTube or unseparated plain red-top or EDTA tube; serum or plasma specimen drawn in a gel-barrier collection tube other than the NMR LipoTube.