Lipid Panel With Diabetes Risk Index (DRI)

Clinical Use

Use

The Diabetes Risk Index (DRI) is intended for use in adult subjects for the quantitative determination of a risk score in serum or plasma. The DRI score (1-100) may be used as an aid in stratifying the risk of developing type 2 diabetes in individuals with normo-glycemia or prediabetes. The Diabetes Risk Index (DRI) is a nuclear magnetic resonance spectroscopy (NMR)-derived multimarker score (values 1-100) that predicts a patient's risk of developing type 2 diabetes mellitus (T2D) independent of glycemic status. DRI derives its performance from the weighted addition of the Lipoprotein Insulin Resistance Index (LP-IR) scores with simultaneously-measured levels of branched-chain amino acids (BCAA).1-6

Special Instructions

Not provided.

Limitations

LDL cholesterol will not be calculated if triglyceride levels are above 800 mg/dL. DRI measurements from plasma specimens are typically 8 points lower than those obtained from serum specimens. This test has not been cleared or approved by the FDA.

Test Details

Methodology

Other

Biomarkers

Cholesterol, totalDiabetes Risk Index (DRI)High-density lipoprotein (HDL) cholesterolLow-density lipoprotein (LDL) cholesterol (calculation)Non-high-density lipoprotein (non-HDL) cholesterol (calculation)Triglycerides

LOINC Codes

Result Codes

2093-3 - Cholest SerPl-mCnc
2571-8 - Trigl SerPl-mCnc
2085-9 - HDLc SerPl-mCnc
43396-1 - NonHDLc SerPl-mCnc
13457-7 - LDLc SerPl Calc-mCnc
94560-0 - Diabetes risk Scre Calc

Result Turnaround Time

1-3 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.5 mL

Container

Plain red-top tube (preferred); NMR LipoTube (black-and-yellow-top tube)

Collection Instructions

Collect specimen in a plain red-top tube (no gel), hold upright at room temperature for 45 minutes to clot, then centrifuge. Transfer to a transport tube for storage at 2°C to 8°C until shipment.

Patient Preparation

Patient fasting is not required but recommended for certain conditions.

Storage Instructions

Refrigerate.

Causes for Rejection

Unspun LipoTube or unseparated plain red-top or EDTA tube; serum or plasma specimen drawn in a gel-barrier collection tube other than the NMR LipoTube.