Lipoprotein-associated Phospholipase A2 Activity
Also known as: PLAC®
Use
The PLAC® test for Lp-PLA2 Activity is an enzyme assay for the in vitro quantitative determination of Lp-PLA2 (lipoprotein-associated phospholipase A2) activity in EDTA plasma and serum. Lp-PLA2 activity is to be used in conjunction with clinical evaluation and patient risk assessment as an aid in predicting risk of coronary heart disease (CHD) in patients with no prior history of cardiovascular events.
Special Instructions
Fasting is not required for this test. Separate serum or plasma from cells as soon as possible (within two hours). Ship refrigerated on cool packs to ensure specimen stability.
Limitations
This test demonstrates modest intra- and inter-individual variation, similar to other cardiovascular lipid markers but with less variability than high sensitivity C-reactive protein (hs-CRP). It is not elevated in systemic inflammatory conditions, making it a more specific marker of vascular inflammation.
Methodology
Automated Analyzer
Biomarkers
LOINC Codes
- 86951-1
- 86951-1
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.2 mL
Container
Red-top tube, gel-barrier tube
Collection Instructions
Separate serum or plasma from cells as soon as possible (within two hours).
Patient Preparation
Fasting is not required.
Storage Instructions
Refrigerate, stable for 14 days. Stable at room temperature for 24 hours and frozen up to 18 months. Ship refrigerated on cool packs.
Causes for Rejection
Hemolyzed samples; excessive turbidity; clots in samples
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 14 days |
| Frozen | 18 months |