Microarray-Products of Conception (POC) Reveal® FFPE
Also known as: aCGH, CGH, CMA, Microarray, Reveal® SNP Microarray-Products of Conception (POC)
Use
This test will detect chromosomal imbalance that could be associated with developmental delay/congenital anomalies. It provides detection of possible uniparental disomy of any chromosome, the percent and location of homozygosity, including the degree of identity by descent. It will also allow the detection of complete or partial molar pregnancies.
Special Instructions
Medical findings should accompany the test request. Inquiries can be directed to genetic customer service at 800-345-4363. Copies of prior NIPT studies should be included with the report. Additional charges may apply for embedding and pathology of formalin-positive tissue samples.
Limitations
The assay does not detect balanced rearrangements or low-level mosaicism below 10%. It is also unable to identify marker chromosomes containing only heterochromatin or tetraploidy. In certain formalin-fixed tissues, genotyping may not be feasible, limiting the assay to genomic dosage determination. The performance characteristics of this test were established by LabCorp and it has not been cleared or approved by the FDA.
Methodology
Microarray
Biomarkers
LOINC Codes
- 94087-4
- 48002-0
- 62377-7
- 62357-9
- 62373-6
- 48672-0
- 11502-2
Result Turnaround Time
14-21 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
One paraffin block or ten 10-micron thick section slides
Minimum Volume
Ten 10-micron thick section slides
Container
Paraffin block transport pouch
Collection Instructions
Specimen should be fixed in 10% neutral-buffered formalin or formaldehyde.
Storage Instructions
Room temperature
Causes for Rejection
Improper preparation, decalcified bone, samples without fetal visualized in the pathology report, or samples with less than 50% fetal content cannot be processed.