Neuromyelitis Optica, IgG Autoantibodies
Also known as: Aquaporin-4, NMO IgG
Use
Establishing the diagnosis of neuromyelitis optica (NMO) and related disorders, including relapsing transverse myelitis or relapsing optic neuritis. Distinguishing NMO and NMO spectrum disorders from multiple sclerosis early in the course of disease. This test can also be used to trigger initiation and monitor effectiveness of therapy.
Special Instructions
If using a red-top tube for specimen collection, ensure the separated serum is transferred to a plastic transport tube.
Limitations
Seronegativity does not exclude NMO diagnosis. Negative results may occur in patients undergoing immunosuppressive therapy. Antibodies may not be present in all patients with NMO, as approximately 10-40% may not have detectable levels.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 68548-7
- 68548-7
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.2 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Collection Instructions
If a red-top tube is used, transfer separated serum to a plastic transport tube.
Storage Instructions
Refrigerate.
Causes for Rejection
Gross lipemia; gross hemolysis; gross icterus
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 14 days |
| Frozen | 14 days |