Non−Small-cell Lung Cancer (NSCLC) Therapeutic Profile II
Use
Non−small-cell lung cancer (NSCLC) is the leading cause of death from cancer in both men and women in the US. A subgroup of NSCLC patients has shown clinical responsiveness to the epidermal growth factor receptor (EGFR) inhibitors gefitinib (Iressa®) and erlotinib (Tarceva®). In the majority of patients with highly responsive tumors, the tumor contains somatic mutations within the EGFR tyrosine kinase domain. The presence of a somatic EGFR mutation is significantly associated with deferential responsiveness or resistance to gefitinib and erlotinib, and is strongly predictive of prolonged survival in NSCLC patients.
Special Instructions
Not provided.
Limitations
The EGFR test is designed to detect mutations in exons 18, 19, 20, and 21 of the EGFR gene. These mutations account for >99% of all reported EGFR mutations in NSCLC patients. The KRAS test is designed to detect mutations in exons 2, 3, and 4 of the KRAS gene. Samples with results reported as "no mutation detected" may harbor mutations that are not detected by the assay.
Methodology
EGFR, KRAS: SNaPshot Multiplex PCR; ALK FISH Analysis
Biomarkers
LOINC Codes
- 21702-6 - KRAS gene Mut Anl Bld/T
- 42349-1
- 31208-2 - Specimen source
- 57723-9 - Unique bar code # Current sample
- 48004-6 - DNA change
- 48005-3 - Amino acid change
- 72486-4 - Lab director name Provider
- 21703-4 - KRAS gene Mut Tested Bld/T
- 49549-9 - Ref lab test method
- 75608-0 - Citation Ref Lab Test
- 8100-0 - Specimen preparation
- 18781-5
- 39111-0 - Bdy site
- 55752-0 - Clinical info
- 62365-2 - Diagnostic imp Spec-Imp
- 77202-0 - Laboratory comment Report
- 19139-5 - Pathologist name
- 51969-4 - Gene analysis narr rpt Doc
- 21665-5 - EGFR gene Mut Anl Bld/T
- 50398-7 - Narrative diagnostic report-Imp
- 21666-3 - EGFR gene Mut Tested Bld/T
- 66746-9 - Specimen type
- 64089-6 - Cells counted CVS
- 64086-2 - Cells analyzed CVS
- 78233-4 - Cells.ALK rear/Cells cnt NFr Bld/T FISH
- 78210-2 - ALK rearrange Bld/T FISH-Imp
- 48672-0 - Clinical cytogeneticist Spec
- 51967-8 - Gene dis assessed
Result Turnaround Time
10-14 days
Related Documents
For more information, please review the documents below
Specimen
Unknown
Volume
Not provided
Minimum Volume
Not provided
Causes for Rejection
Block containing no tumor tissue; decalcified specimens; broken or stained slides
Other tests from different labs that may be relevant