Platelet Antibody Profile
Also known as: Antiplatelet, Circulating Platelet Antibodies, Indirect Platelet Antibodies, Platelet Antibodies, Qualitative
Use
Screen for the presence of circulating antibodies to platelets (not bound to the platelet surface), that may be associated with the destruction of platelets.
Special Instructions
If a newborn has a significantly low platelet count and neonatal alloimmune thrombocytopenia purpura (NAIT) is suspected, a serum platelet antibody test should be ordered on both the mother and the child. The work-up for NAIT includes evaluation for platelet reactive antibodies and typing of maternal and paternal platelet glycoproteins. Platelet antibody production can cause platelet refractoriness, though other potential causes include sepsis, DIC, or drug-induced thrombocytopenia.
Limitations
The assay is not designed to detect antibodies related to heparin-induced thrombocytopenia or other drug-associated thrombocytopenias. Some low titer, low avidity antibodies may not be detected using this assay. It may also not detect antibodies that are platelet-bound or cleared.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 95270-5
- 48501-1
- 48505-2
- 48506-0
- 47084-9
- 43302-9
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
Not provided
Container
Red-top tube or gel-barrier tube
Collection Instructions
Separate serum from red cells. Transfer serum to a plastic transport tube.
Storage Instructions
Refrigerate for up to 48 hours, freeze if longer storage is needed.
Causes for Rejection
Hemolysis; serum not separated from cells