PML/RARA FISH Panel

Clinical Use

Order Test

Use

Fluorescence in situ hybridization (FISH), acute myelocytic leukemia (AML), and PML/RARA

Special Instructions

Not provided.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration. Additionally, any FISH study should avoid using EDTA tubes if sharing with a karyotype study due to growth inhibition in cell culture.

Test Details

Methodology

Chromosomal / Cytogenetics (FISH)

Biomarkers

No genes

Gene

FISH Result

Copy Number Alteration • Categorical (e.g., Positive / Negative / Indeterminate)

LOINC Codes

Order Codes

31208-2 - Specimen source
48672-0 - Clinical cytogeneticist Spec
48674-6 - Genetic diseases Bld/T FISH
62360-3 - Cells analyzed
62361-1 - Cells counted
77031-3 - t(15;17)(PML,RARA) Bld/T FISH

Result Codes

62361-1 - Cells counted
62360-3 - Cells analyzed
48674-6 - Genetic diseases Bld/T FISH
77031-3 - t(15;17)(PML,RARA) Bld/T FISH
31208-2 - Specimen source
48672-0 - Clinical cytogeneticist Spec

Result Turnaround Time

3-5 days

Specimen

Whole Blood

Volume

5 mL

Minimum Volume

1 mL

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal).

Collection Instructions

Utilize sterile technique and Labcorp transport kits when possible.

Storage Instructions

Transport to the testing laboratory at room temperature; use of a cool pack or a Labcorp transport kit is acceptable. Do not allow samples to overheat or freeze.