FISH, APL, PML/RARA, Translocation 15,17
Also known as: Acute Promyelocyticleukemia, FISH-Acute Promyelocyticleukemia, Promyelocytic Leukemia
Use
This FISH assay detects the t(15;17)(PML‑RARA) translocation, which is diagnostic for acute promyelocytic leukemia (APL) and is required to predict response to all‑trans‑retinoic acid and arsenic trioxide therapy. It is also used for monitoring therapeutic response, minimal residual disease (MRD), and early relapse, and reflex testing with a RARA break‑apart probe identifies variant RARA rearrangements when morphology is suspicious but t(15;17) is negative.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL (3 mL minimum)
Minimum Volume
3 mL
Container
sodium heparin (green‑top) or EDTA (lavender‑top) tube; acceptable: sodium heparin (royal blue‑top) or sodium heparin lead‑free (tan‑top) tube
Other tests from different labs that may be relevant