Porphyrins, Quantitative, Random Urine

Also known as: Coproporphyrin, Uroporphyrin

Clinical Use

Use

Urine porphyrins are useful for the evaluation of cutaneous photosensitivity to exclude porphyria cutanea tarda (PCT). Evaluation of neurologic and/or psychiatric symptoms associated with acute porphyrias, such as acute intermittent porphyria (AIP), requires urine porphobilinogen (PBG) testing. Refer to Porphobilinogen (PBG), Quantitative, Random Urine [003065].

Special Instructions

Not provided.

Limitations

Results may be affected by the loss of specimen integrity due to exposure to light or lack of refrigeration. Acidic pH or the presence of acid preservatives can compromise the sample quality. The test does not substitute for urine porphobilinogen (PBG) testing when evaluating symptoms associated with acute porphyrias.

Test Details

Methodology

Chromatography (High-pressure liquid chromatography (HPLC) with fluorometric detection)

Biomarkers

6 targets

Coproporphyrin (CP) ICoproporphyrin (CP) IIIHeptacarboxylporphyrins (7-CP)Hexacarboxylporphyrins (6-CP)Pentacarboxylporphyrins (5-CP)Uroporphyrins (UP)

LOINC Codes

Result Codes

11228-4 - Uropor Ur-mCnc
2407-5 - Hepta-CP Ur-mCnc
27400-1 - Hexa-CP Ur-mCnc
11221-9 - Penta-CP Ur-mCnc
9343-5 - Copro1 Ur-mCnc
9345-0 - Copro3 Ur-mCnc

Result Turnaround Time

3-5 days

Specimen

Urine

Volume

2 mL

Minimum Volume

1.5 mL

Container

12-mL amber plastic transport tube without preservative

Collection Instructions

Transfer required aliquot into a LabCorp amber plastic transport tube with amber cap (LabCorp No. 23598). If unavailable, cover tube completely with aluminum foil and secure with tape. Label with patient's name.