Porphyrins, Fractionation and Quantitation, Urine
Also known as: PORURINE
Use
This test is used to evaluate cutaneous photosensitivity and to exclude or confirm the diagnosis of porphyria cutanea tarda (PCT). Elevated concentrations of urine uroporphyrin and heptacarboxyl, hexacarboxyl, and pentacarboxyl porphyrins suggest porphyria cutanea tarda, typically associated with cutaneous photosensitivity. Additionally, this test includes creatinine normalization to aid in interpretation, especially beneficial for samples with variable collection times and volumes.
Special Instructions
Not provided.
Limitations
Results are normalized to creatinine concentration and expressed as a ratio of micromoles of porphyrin per mole of creatinine. Interpretation should consider deviations in collection time or urine volume. For neurologic and psychiatric symptom evaluation related to acute porphyrias, urine porphobilinogen testing is required.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 35674-1 - Creat ?Tm Ur-mCnc
- 2162-6 - Creat 24h Ur-mRate
- 32043-2 - Uropor/Creat 24h Ur-sRto
- 38175-6 - Heptacarboxylate/Creat Ur-sRto
- 49292-6 - Porphyrin Fract 24h Ur-Imp
- 19153-6 - Specimen vol ?Tm Ur
- 30211-7 - Specimen collect Time Spec
- 45313-4 - Copro1/Creat Ur-sRto
- 45315-9 - Copro3/Creat Ur-sRto
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
4 mL
Minimum Volume
2 mL
Container
ARUP Amber Transport Tube
Collection Instructions
24-hour or random urine collection. Must be refrigerated during collection. Protect from light. Record total volume and collection time interval on transport tube and test request form.
Storage Instructions
Frozen.
Causes for Rejection
Body fluids other than urine.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 4 days |
| Frozen | 1 month |
Other tests from different labs that may be relevant