PrEP Use Only: HIV Antigen/Antibody and HIV RNA, Qualitative
Also known as: HIV PrEP, pre-exposure prophylaxis screening for HIV
Use
PrEP use only: This profile includes HIV p24 antigen/antibody with reflex to antibody differentiation and HIV-1/2 qualitative RNA to support baseline assessment and monitoring of patients on PrEP for HIV infection.
Special Instructions
Not provided.
Limitations
Reactive results for the HIV p24 antigen/antibody require additional supplemental testing for confirmation. A negative result does not exclude the possibility of HIV-1 or HIV-2 infection, particularly if the presence of the marker is below detectable levels or absent at the specimen collection time. The test's limitations include the potential for non-detection during certain disease stages or due to specimen handling discrepancies.
Methodology
Immunoassay (EIA)
Biomarkers
LOINC Codes
- 75622-1 - HIV 1 and 2 - MU Set
- 56888-1 - HIV 1+2 Ab+HIV1 p24 Ag SerPl Ql IA
- 25835-0 - HIV1 RNA SerPl Ql NAA+probe
- 69353-1 - HIV 2 RNA SerPl Ql NAA+probe
- 55752-0 - Clinical info
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2.5 mL
Minimum Volume
1.5 mL
Container
Gel-barrier tube
Collection Instructions
Collect using the usual blood collection technique. Do not freeze serum gel tubes; send to the lab refrigerated. Send frozen or refrigerated serum for RNA test in serum pour-off tube.
Patient Preparation
Stop biotin consumption at least 72 hours prior to collection.
Storage Instructions
HIV Ag/Ab: Gel-barrier tubes refrigerated up to 7 days. HIV RNA: Frozen up to 6 weeks or refrigerated up to 7 days.
Causes for Rejection
Hemolysis; lipemia; incorrect handling; labeling errors; use of expired or inappropriate transport devices.
Stability Requirements
| Temperature | Period |
|---|---|
| Refrigerated | 7 days |
| Frozen | 6 weeks |
Other tests from different labs that may be relevant