VistaSeq® Brain/CNS/PNS Cancer Panel
Also known as: Familial Cancer testing, Hereditary Cancer testing, Inherited Cancer testing
Use
This assay is intended for patients with a family history consistent with an inherited cancer syndrome.
Special Instructions
Not provided.
Limitations
Sequencing cannot detect variants in regions not covered by this analysis, including noncoding or deep intronic variants, and may not reliably detect changes in repetitive elements such as microsatellite repeats. It may not detect mosaic variants, inversions, or genomic rearrangements like transposable element insertions. Sequence analysis is affected by allele drop-out due to the presence of a rare variant under a primer site or in homopolymeric regions. This analysis doesn't conclude about whether two heterozygous variants are on the same or different chromosome copies. Copy number variations analysis might miss certain rearrangements like translocations and inversions. Pseudogenes can hinder variant detection in specific genes. The test does not identify somatic variants and results are impacted by bone marrow transplants.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 73977-1 - Cancer multigene analysis Bld/T
- 31208-2 - Specimen source
- 51968-6 - Gene dis anl interp-Imp
- 69548-6 - Genetic var assess
- 47042-7 - Counseling note
- 77202-0 - Laboratory comment Report
- 49549-9 - Ref lab test method
- 75608-0 - Citation Ref Lab Test
- 72486-4 - Lab director name Provider
- 51969-4 - Gene analysis narr rpt Doc
Result Turnaround Time
23-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
7 mL
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collection Instructions
Blood is collected by routine phlebotomy.
Storage Instructions
Room temperature
Causes for Rejection
Frozen specimen; leaking tube; clotted specimen; grossly or hemolyzed specimen; quantity not sufficient; incorrect anticoagulant.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 days |
| Refrigerated | 60 days |
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