Special Instructions

A hereditary cancer clinical questionnaire should be submitted with all specimens. Contact CMBP genetic services at 800-345-4363 to coordinate testing. To order Oragene Dx 500 saliva collection kits using PeopleSoft No. 87917, contact your local Labcorp branch supply department.

Limitations

Sequencing cannot detect variants in regions not covered by this analysis, including noncoding or deep intronic variants, and may not reliably detect changes in repetitive elements such as microsatellite repeats. It may not detect mosaic variants, inversions, or genomic rearrangements like transposable element insertions. Sequence analysis is affected by allele drop-out due to the presence of a rare variant under a primer site or in homopolymeric regions. This analysis doesn't conclude about whether two heterozygous variants are on the same or different chromosome copies. Copy number variations analysis might miss certain rearrangements like translocations and inversions. Pseudogenes can hinder variant detection in specific genes. The test does not identify somatic variants and results are impacted by bone marrow transplants.

Biomarkers

LOINC Codes

Result Turnaround Time

Related Documents

Stability Requirements