Comprehensive Hereditary Cancer Panel

Casandra

Casandra Test Code QD02287Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 38600CPT Codes 81432, 81433

Comprehensive Hereditary Cancer Panel

Also known as: Qvantage, BRCA, 34 Gene Panel, BRACA, BRCA1/2

Clinical Use

Order Test

Use

This multigene panel is used to identify individuals with a hereditary predisposition to cancer, particularly when personal or family history does not clearly indicate a specific syndrome or when smaller genetic tests are negative despite strong suspicion of inherited risk. It is applicable to individuals with personal and/or family history of multiple cancer types or negative prior targeted testing. Informed consent and genetic counseling are recommended components of test use. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq217?utm_source=openai))

Special Instructions

Not provided.

Limitations

This test is limited to the specified 66 genes and may not detect all hereditary cancer predisposition causes or variants outside the regions covered. It is not optimized for every cancer type, and rare or novel variants may remain unclear. False positives or negatives may occur; results should be interpreted with clinical context, history, and potentially additional testing. ([questdiagnostics.com](https://www.questdiagnostics.com/healthcare-professionals/clinical-education-center/faq/faq217?utm_source=openai))

Test Details

Methodology

NGS (Targeted)

Biomarkers

Mutation (66 genes)

APCATMAXIN2BAP1BARD1BLMBMPR1ABRCA1BRCA2BRIP1CDH1CDK4CDKN1BCDKN2ACHEK2DICER1EGFREPCAMFANCAFANCCFANCMFHFLCNGALNT12GREM1HOXB13MAXMEN1METMITFMLH1MRE11MSH2MSH3MSH6MUTYHNBNNF1NTHL1PALB2PMS2POLD1POLEPOT1PTCH1PTENRAD50RAD51CRAD51DRECQLRETSDHASDHAF2SDHBSDHCSDHDSMAD4SMARCA4STK11SUFUTMEM127TP53TSC1TSC2VHLXRCC2