VistaSeq® Hereditary Cancer Panel
Use
This assay is intended for patients with a family history consistent with an inherited cancer syndrome.
Special Instructions
Not provided.
Limitations
Sequencing cannot detect variants in regions not covered by this analysis, including noncoding or deep intronic variants, and may not reliably detect changes in repetitive elements such as microsatellite repeats. It may not detect mosaic variants, inversions, or other genomic rearrangements such as transposable element insertions. Sequence analysis might also be affected by allele drop-out due to rare variants under primer sites or homopolymeric regions. Copy number variations analysis may not detect certain genomic rearrangements like translocations or some partial exon rearrangements, and pseudogenes can interfere with the detection of variants in certain genes. This test is not intended for detecting somatic variants, and bone marrow transplantation may affect results.
Methodology
NGS (Targeted)
Biomarkers
LOINC Codes
- 73977-1 - Cancer multigene analysis Bld/T
- 31208-2 - Specimen source
- 51968-6 - Gene dis anl interp-Imp
- 69548-6 - Genetic var assess
- 47042-7 - Counseling note
- 77202-0 - Laboratory comment Report
- 49549-9 - Ref lab test method
- 75608-0 - Citation Ref Lab Test
- 72486-4 - Lab director name Provider
- 51969-4 - Gene analysis narr rpt Doc
Result Turnaround Time
21-28 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
10 mL
Minimum Volume
7 mL
Container
Lavender-top (EDTA) tube or yellow-top (ACD) tube
Collection Instructions
Blood is collected by routine phlebotomy.
Storage Instructions
Room temperature
Causes for Rejection
Frozen specimen; leaking tube; clotted specimen; quantity not sufficient for analysis; grossly hemolyzed specimen; incorrect anticoagulant.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 60 days |
| Refrigerated | 60 days |
Other tests from different labs that may be relevant