Hereditary Colorectal Cancer Panel

Also known as: MYH, Multi-Gene Cancer, Colorectal polyps, Colon polyps, CHECK2

Clinical Use

Use

This Hereditary Colorectal Cancer Panel includes 20 genes associated primarily with hereditary gastrointestinal cancers and possibly other cancers — including colon, endometrium, stomach, urinary tract, ovary, pancreas, prostate, and rectum. Individuals with a positive result (pathogenic or likely pathogenic variant detected) have an increased risk for developing certain cancers relative to that of the general population.

Special Instructions

Not provided.

Limitations

This test cannot detect all causes of hereditary predisposition to colorectal cancer. It is limited to the 20 genes on the panel and does not examine every gene region associated with hereditary colorectal cancer, so variants in unexamined regions may be missed. The panel is not optimized for other cancer types outside gastrointestinal indications. Rare or novel variants may have unclear effects; rare false-positive or false-negative results may occur. Results should be interpreted in context of clinical findings and family history, and additional genetic testing may sometimes be appropriate.

Test Details