Zonisamide, Serum or Plasma
Also known as: Zonegran®
Use
Monitor drug levels for optimal therapy
Special Instructions
Samples should be collected immediately prior to the patient's next dose. Zonisamide is contraindicated in patients with hypersensitivity to sulfonamides or zonisamide. Consider discontinuing the drug if an unexplained rash develops, and frequently observe patients if the drug is discontinued.
Limitations
This test may be affected by drug half-life alterations when co-administered with P450 inducers like phenytoin and carbamazepine, leading to reduced zonisamide half-life. Results may not be accurate for patients with conditions or medications affecting metabolic pathways involving CYP3A4 and CYP2D6 enzymes.
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 29620-2
- 29620-2
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
Red-top tube, sodium heparin tube, potassium EDTA tube or lithium heparin tube
Collection Instructions
Separate serum from cells within 45 minutes of collection and transfer to a plastic transport tube.
Patient Preparation
Collect samples immediately prior to next dose.
Storage Instructions
Room temperature
Causes for Rejection
Hemolyzed samples; gel separator tubes; clotted specimen; samples not separated from blood cells
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 14 days |
| Refrigerated | 7 days |
| Frozen | 4 weeks |