Chronic Lymphocytic Leukemia, IgVH Mutation Status
Also known as: Immunoglobulin VH Gene Mutation, IgVH Mutation Analysis, CLL, IgVH Mutation Status, Cell-based
Use
B cell chronic lymphocytic leukemia (B‑CLL) shows highly variable clinical behavior. IGVH (immunoglobulin heavy‑chain variable region) mutation status divides patients into two prognostically distinct groups. Patients whose IGVH genes are mutated (≥2% deviation from germline, <98% homology) generally have longer survival and may require less intensive therapy; those with unmutated IGVH display more aggressive disease courses and shorter survival. This test assesses IGVH mutation status to aid in risk stratification and management decisions.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
NGS
Biomarkers
LOINC Codes
- 48670-4 - IgVH gene Mut Anl Bld/T
Result Turnaround Time
7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL whole blood
Minimum Volume
3 mL
Container
EDTA (lavender‑top) tube
Storage Instructions
Ship sample refrigerated
Causes for Rejection
Moderate hemolysis; Gross hemolysis; Lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |
| Frozen | Unacceptable |
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