Use

Leucine‑rich glioma‑inactivated 1 (LGI1) antibody testing is used in the evaluation of autoimmune encephalitis, particularly VGKC‑complex limbic encephalitis. It is often considered when patients present with cognitive impairment, seizures, faciobrachial dystonic seizures, psychiatric symptoms, and refractory hyponatremia, as early detection can guide immunotherapy and improve outcomes.