Metanephrines, Fractionated, LC/MS/MS, 24‑Hour Urine
Also known as: Normetanephrine, Metanephrine
Use
This test measures the fractionated metanephrines—metanephrine and normetanephrine—in a 24‑hour urine collection as an aid in the evaluation of catecholamine-secreting tumors such as pheochromocytoma and paraganglioma.
Special Instructions
Collect a complete 24‑hour urine with the addition of 25 mL 6 N HCl to maintain pH ≤ 3; if no preservative is used, the urine must be refrigerated during collection and shipped frozen, with pH ≤ 6. Record total 24‑hour volume and patient age on requisition and container. Unacceptable if urine contains boric acid.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
Result Turnaround Time
2-4 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
Not provided
Minimum Volume
Not provided
Container
24‑hour urine container
Collection Instructions
Collect 24‑hour urine with 25 mL 6 N HCl to maintain a pH ≤ 3. If no preservative is used, specimen must be stored refrigerated during collection but shipped frozen and pH must be ≤ 6. Record 24‑hour volume and patient's age on test request form and urine vial.
Causes for Rejection
Urine collected with boric acid
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 10 days (preserved urine) |
| Refrigerated | 14 days (preserved urine) |
| Frozen | 90 days (preserved); 30 days (unpreserved) |