Primidone and Phenobarbital
Also known as: Mysoline
Use
Monitoring of serum primidone and its active metabolite phenobarbital is useful for assessing patient compliance with therapy, ensuring therapeutic drug levels are reached and maintained, and detecting potential drug toxicity.
Special Instructions
Collect specimen as trough level just prior to next dose.
Limitations
Specimens collected in serum separator tubes (SST) or tubes with additives are rejected. Levels should be drawn at trough to reflect steady‑state exposure; improper timing or collection can affect interpretation.
Methodology
Immunoassay (Other)
Biomarkers
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.2 mL
Container
Red‑top tube (no gel)
Collection Instructions
Collect as trough just prior to next dose
Storage Instructions
Refrigerated
Causes for Rejection
Serum separator tube or any serum collection tube with additives
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 7 days |
| Frozen | 30 days |