Rabies Vaccine Response End‑Point Titer (5789X)
Use
This test (also known as Rabies Virus Neutralizing Antibodies, RVNA) measures the neutralizing activity of rabies-specific antibodies using the Rapid Fluorescent Foci Inhibition Test (RFFIT). It assesses whether protective immunity has been achieved following vaccination by determining the endpoint titer (e.g., dilution titer or IU/mL), guiding decisions regarding booster doses and confirming immune response in individuals at occupational or exposure risk.
Special Instructions
Not provided.
Limitations
This assay uses a live-virus biological system with variability across reference serum titers per batch; results depend on calculation with the measured batch reference. Interpretation thresholds differ: ACIP considers complete neutralization at serum dilution of 1:5 (≈0.1 IU/mL) adequate, whereas WHO guideline is ≥0.5 IU/mL. The lower limit of accurate detection is 0.1 IU/mL.
Methodology
Other
Biomarkers
Rabies Vaccine Response (neutralizing antibodies)
Other
Result Turnaround Time
21-28 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2‑4 mL
Minimum Volume
1 mL
Container
Red Top (No Additive)
Causes for Rejection
Gross hemolysis; Gross lipemia
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 10 days |
| Frozen | 30 days |
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