Thiopurine Metabolites
Also known as: 6-Methylmercaptopurine (6-MMP), 6-MP, 6-Thioguanine (6-TG), AZA
Use
Thiopurine Metabolites testing measures levels of 6‑Mercaptopurine (6‑MP) metabolites—specifically 6‑Thioguanine (6‑TG) and 6‑Methylmercaptopurine (6‑MMP)—to monitor therapeutic compliance and guide dosing adjustments in patients on thiopurine drugs. It assists clinicians in balancing efficacy and toxicity risk in treatment regimens such as for inflammatory bowel disease.
Special Instructions
Not provided.
Limitations
Not provided.
Methodology
Mass Spectrometry
Biomarkers
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
2.5 mL
Container
EDTA (lavender‑top) tube
Collection Instructions
A trough specimen is required (within 1 hour prior to the next dose)
Patient Preparation
Trough specimen (within 1 hour prior to next dose)
Causes for Rejection
Hemolysis; Heparin whole blood; Received frozen
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 7 days |
| Frozen | Unacceptable |