Casandra
Casandra Test Code QD78118Version 1 (DRAFT)
Performing Lab
Cholinesterase, Serum, with Dibucaine Inhibition
Clinical Use
Order TestUse
The Pseudocholinesterase phenotype can be determined by analysis of Pseudocholinesterase activity and percent inhibition by dibucaine. Approximately 96% of the population has normal activity; around 4% exhibit decreased activity leading to prolonged paralysis following succinylcholine administration, and about 1 in 3,000 patients experience severe, prolonged paralysis following anesthetic exposure.
Special Instructions
Not provided.
Limitations
Elevated values caused by presence of young red blood cells and reticulocytes may mask acetylcholinesterase inhibition.
Test Details
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
Cholinesterase, Serum
AnalyteCholinesterase, Serum
Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
Dibucaine Number
AnalyteDibucaine Number
Concentration / Level • Quantitative (Continuous) (e.g., copies/mL, % expression)
Result Turnaround Time
2 days
Related Documents
For more information, please review the documents below
Specimen Requirements
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Red top (no additive)
Causes for Rejection
Hemolysis
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 21 days |
| Refrigerated | 21 days |
| Frozen | 30 days |
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