Coccidioides Antibodies by Complement Fixation and Immunodiffusion, Serum

Casandra

Casandra Test Code AR09906Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3002995CPT Code 86635

Coccidioides Antibodies by Complement Fixation and Immunodiffusion, Serum

Also known as: COCC.CFIDS

Clinical Use

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Use

This test aids in the diagnosis of coccidioidomycosis, a fungal infection caused by Coccidioides species. It includes testing by complement fixation and immunodiffusion, which are used to detect antibodies in the serum. A titer of 1:2 or greater suggests past or current infection, but more than 30 percent of chronic cases may have negative results. Complement fixation serology can also be used to monitor therapy, and the presence of antibodies in cerebrospinal fluid is considered diagnostic for coccidioidal meningitis.

Special Instructions

Parallel testing is preferred. Convalescent specimens must be received within 30 days from receipt of the acute specimens. Ensure specimens are marked as 'acute' or 'convalescent'.

Limitations

Negative results do not exclude the possibility of a Coccidioides infection, especially in cases with chronic residual pulmonary disease. Titers less than 1:32 may indicate past infection or self-limited disease. Additionally, 10 percent of patients with coccidioidal meningitis may not have antibodies in CSF. Unrelated antibodies detected with immunodiffusion may suggest other systemic fungal infections.

Test Details

New York Approved