Echovirus Antibodies

Casandra

Casandra Test Code AR28534Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0060053CPT Code 86658

Also known as: ECHO

Clinical Use

Order Test

Use

This test is used to detect neutralizing antibodies for echovirus types 6, 7, 9, 11, and 30. The presence of these antibodies, especially when titer levels are greater than or equal to 1:80, may indicate a past or current echovirus infection. Seroconversion or a fourfold increase in antibody titers between acute and convalescent serum samples is considered strong evidence of a current or recent infection.

Special Instructions

PCR testing is preferred for diagnosing acute echovirus infection. It is important to mark samples clearly as 'acute' or 'convalescent' and ensure that convalescent samples are received within 30 days from the collection of acute samples.

Limitations

This test is limited to detecting neutralizing antibodies for the specified echovirus types: 6, 7, 9, 11, and 30. It cannot differentiate between past and current infections solely based on a positive result; clinical correlation and further testing, such as PCR, may be necessary for acute diagnosis. The test is not suitable for identifying other echovirus types or any other viral infections. Also, false positives may occur due to cross-reactivity with other enteroviruses or in individuals previously vaccinated or exposed. Additionally, conditions like hemolysis, lipemia, or contamination can compromise specimen integrity, rendering them unacceptable.

Test Details

New York Approved

Methodology

Immunoassay (Other)

Biomarkers

5 targets

Echovirus Type 11Echovirus Type 30Echovirus Type 6Echovirus Type 7Echovirus Type 9

LOINC Codes

Result Codes

5144-1
41492-0
41489-6
41491-2
5146-6

Result Turnaround Time

6-12 days

Specimen

Serum

Volume

1 mL

Minimum Volume

0.3 mL

Container

ARUP Standard Transport Tube

Collection Instructions

Separate serum from cells as soon as possible or within 2 hours of collection. Transfer 1 mL serum to an ARUP Standard Transport Tube. Ensure convalescent samples are received within 30 days from receipt of acute samples.