FISH, AML, CBFB/MYH11, Inversion 16
Also known as: Acute Myelomonocytic Leukemia, CBFB/MYH11 Gene Rearrangement, AML M4
Use
This FISH assay detects CBFB gene rearrangements, including inversion 16 and t(16;16), to aid in the diagnosis of acute myeloid leukemia (AML) with CBFB‑MYH11 fusion. It is useful for identifying core‑binding factor AML subtype associated with favorable prognosis.
Special Instructions
Not provided.
Limitations
Specimen viability is sensitive to transit and handling; if viability is compromised or result isn’t possible, test may be canceled. Frozen specimens are not acceptable; viability must be determined at the testing laboratory.
Methodology
Chromosomal / Cytogenetics (FISH)
Biomarkers
Unknown CNV
Copy Number RegionUnknown CNV
Copy Number Region
Result Turnaround Time
5 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
1 mL
Container
sodium heparin (green‑top) tube
Collection Instructions
Preferred whole blood: 5 mL in sodium heparin tube; viability decreases during transit; do not freeze
Storage Instructions
Do not freeze
Causes for Rejection
Received frozen
Other tests from different labs that may be relevant