FISH, CML/ALL, bcr/abl Translocation 9;22

Casandra

Casandra Test Code QD31044Version 1 (DRAFT)

Performing Lab

Lab Quest DiagnosticsLab Test ID 12070CPT Codes 88271, 88275

FISH, CML/ALL, bcr/abl Translocation 9;22

Also known as: CML, ALL, Philadelphia Chromosome, Chronic Myelogenous Leukemia (CML), Acute Lymphoblastic Leukemia (ALL)

Clinical Use

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Use

This test uses fluorescence in situ hybridization (FISH) to detect molecular rearrangement of the BCR and ABL1 genes involved in t(9;22). The Philadelphia chromosome (Ph) resulting from this translocation is associated with chronic myelogenous leukemia (CML), de novo acute myeloid leukemia (AML), and acute lymphocytic leukemia (ALL). It may also be used in evaluation of Ph‑negative CML and complex rearrangements.

Special Instructions

Clinical history and reason for referral are required with test order. Prior therapy and bone marrow transplant history should be provided. Insurance authorization may be required for outpatients; inpatients may be okay to send without prior authorization.

Limitations

Specimen viability decreases during transit. Specimens must not be frozen; if not viable, the test order may be canceled and replaced by a "Cytogenetics Communication" order.

Test Details